Dual Fluorescent Molecular Probes
Fluorescent Probes for Biomedical Analytes: Cardiac Troponin I  

Problem:
Single band emission dyes do not allow for consistent and accurate detection of analyte. Photobleaching and lamp intensities vary.

Solution:  New class of dual fluorescent dyes offer ratiometric signals and internal calibration.

Nandhikonda, P.; Heagy, M.D. Org. Lett. 2010, 4796-4799.

Nandhikonda, P.; Heagy, M.D.; J. Am. Chem. Soc., 133, 14972-14974, 2011

 

 

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Solar Fuels via Chemical Carbon Mitigation of CO2

Blue print for our development of
solar conversion

 

 

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Dual Fluorescent Probe for the G4-Quadruplex
Implications in Cell Senescence, Origins of Cancer  

Problem:
The G4 structure has been recently recognized as a major factor in programmed cell death. 
Can it be detected in a quantitative manner via fluorescence

Proposed Solution:  Develop dual fluorescent dyes with specificity for the G4 structure.

Four guanadine groups centered about K+ atom promotes the unique Hoogsteen base pairing

 

 
 

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Panchromatic dyes for new White Organic Light Emitting Devices WOLEDs

Naphthalimide based dyes  

Matrix emission scan of panchromatic dye

 

 

Multicolor emission from single excitation wavelength

 

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