Room 317, Jones Annex New Mexico Institute of Mining and Technology (NM Tech) 801 Leroy Place Socorro NM 87801 Phone (505) 835-5300 FAX (505) 835-5668 email: smoake@nmt.edu

Classes

Research Interests

• Pharmacological studies of peripheral membrane cyclic AMP phosphodiestrases.
• Attachment of plasma membrane cyclic AMP phosphodiestrase
• Mechanisms of insulin activation and thyroid hormone inhibition of cyclic AMP phosphodiesterases.
• Naturally-occuring inhibitors of calmodulin.

Education

Ph.D. Zoology University of Tennessee, Knoxville TN, 1969

M.S. Zoology University of Tennessee, Knoxville TN, 1966

B.A. Biology , Jacksonville State University, Jacksonville AL, 1965

Employment

Chairman, Biology Department, NM Tech, 1998-2004.

Professor of Biology NM Tech 1984-present.

Dean of Graduate Studies, New Mexico Tech, Socorro, NM June 1986. Resumed after sabbatical leave, August 1987-1997.

Sabbatical leave with Dr John Dedman, Department of Cell Biology, University of Texas health Science Center, Houston TX, July 1986-August 1987.

Chairman, Biology Department, NM Tech, Socorro, NM July 1981-August 1986.

Adjunct research Associate Professor, Department of Medicine, University of New Mexico, Albuquerque 1978-1987.

Sabbatical leave with Dr S. S. Solomon, Endocrine and Metabolism Section, VA Medical Center, Memphis TN, July 1979-July 1980.

Associate Professor of Biology, NM Tech, Socorro, NM. August 1973-May 1984.

Assistant Professor of Biology, NM Tech, Socorro, NM. August 1973-My 1978.

Postdoctoral Fellow with Dr w Y Chueng, St Jude's Research Hospital, Memphis TN. April 1972.

Research Physiologist (Capt US Army) Physiology Laboratory, US Army Reserach Institute of Environmental Medicine, Natlick MA. June 1969-April 1972.

Publications

Solomon S.S., Palazolo, M.R., Smoake, J.A. and Raghow, R.S. 1995. Insulin-stimulated calmodulin gene expression in rat H-41E cells can be selectively blocked by antisense oligonucleotides. Biochem Biophys Res Commun. 210: 921-930..

Smoake, J.A. and Solomon, S.S. 1989. Insulin Control of phosphodiesterase. Life Science 45: 2255-2268.

Solomon, S.S., Deaton, J.G. and Smoake J.A. 1989. Studies of insulin resistance in Streptozotocin diabetic and BB Rat: Activatin of low KM AMp phosphodiesterase by insulin. Amer.J. Med. Sci. 297: 372-376.

Peake, G.T. and Smoake, J.A. 1985. Regulation by calmodulin of adenylate cyclase activiety in anterior pituitary. Endocrinology 116: 2098-2102.

Rao, R.H., Palazzolo, M., Saunders, L. Smoake, J.A. and Solomon, S.S. 1984. Properties and charachetization of low molecular wieght inhibitor of calmodulin-dependent AMP phosphodiesterase from rat liver. Life Sciences 35: 2155-2164.

Solomon, S.S., Palazzolo, M., McPherson, J. and Smoake, J.A. 1981. Effects of Experimental Diabetes and Insulin on cyclic AMP phosphodiesterase and its protein activator in rat adipo tissue. Diabetes 30: 373-376.

Smoake, J.A., McMahon, K.L., Wright, R.K. and Solomon, S.S. 1981. Hormonally sensitive cyclic AMP phosphodiesterase in liver cells: An exto-enzyme. J. Biol. Chem. 256: 8531-8535.

Smoake, J.A., Johnson, L.S. and Peak, G.T. 1981. Calmodulin-dependent high affinity phosphodiesterase in liver membranes. Arch Biochem. Biophys. Res. Commun. 94: 424-430.

Smoake, J.A. and Solomon, S.S. 1980. Subcellular chifts in cyclic AMP phosphodiesterase and its calcium-dependent regulator in liver: role of the diabietic. Biochem. Biophys. Res. Commun. 94: 424-430.

Smoake J.A., Mulvey Jr., P.F., Gerben, M. and Jones, L.G. 1977. Oxygen consumption and thyroid function in squirrel monkey. Laboratory Animal Science 27: 655-658.

Cheung, W.Y., Lin, Y.M., Liu, Y.P. and Smoake, J.A. 1975. Regulation of bovine cyclic -3' 5' nucleotide phosphodiesterase by its protein activator. In cyclic nucleotides in diseases. B. Weiss, ed. University Park Press. Baltimore, pp 321-350.

Smoake, J.A., Song, S.Y. and Cheung, W. Y. 1974. Cyclic-3', 5' nucleotide phosphodiesterase. Distribution and develpmental changes of the the enzyme and its protein activator in mammalian tissues and cells. Biochem, Biophus. Acta 341: 402-411.

Bowers, Jr., W.D., Hubbard, R.W., Smoake, J.A, Daum, R.C. and Nilson. 1974. Effects of exercise on the ultra-structure of skeletal muscle. Amer. J. Physiol. 227: 313-316.

Hubbard, R.W., Mathew, W.T., Linduska, J.D. Smoake, J.A. and Bowers, W.D. 1974. The effects of growth and endurance training on the sytochrome C content of rat solus, plantaris, and gastrocnemius muscles. Growth 38: 529-534.

Hubbard, R.W. Smoake, J.A., Mathew, W.T. Linduska, J.D. and Bowers, W.D. 1974. The effects of growth and endurance training and the protein adn DNA content of rat soleus, plantaris and gastrocnemius muscle. Growth 38: 171-185.

Therriault, D.G., Beller, G.A. Smoake, J.A. and Hartley, L.H. 1973. Intrasmuscular energy sources in dogs during physical work. J.Lipid Res. 14: 54-60

Smoake, J.A.1972. Another way to induce high altitude pulmonay edemain monkeys. Amer. Review. Resp. Dis. 105: 856.

Gerben, M.J., Jones, L.G. and Smoake, J.A. 1971. Behavioral tolerance and squirrel monkeys to hypoxia: A model for evaluating drug therapy. Behav. Res. Meth & Instru. 3:10-12.